Restoration of miR-29b exerts anti-cancer effects on glioblastoma
نویسندگان
چکیده
منابع مشابه
miR-29b
Multiple myeloma (MM) is a heterogeneous disease originating from the transformation of a post-germinal center B cell. MM pathogenesis is a multistep process with chro-mosomal changes, genetic and epigenetic events occurring at different stages during the course of the disease. 1 MicroRNAs (miRNAs) are well known to be transcriptional repressors, possessing tumor suppressor (Ts) or oncogenic fu...
متن کاملMicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
Epithelial ovarian cancer (EOC) is the most lethal and aggressive gynecological malignancy, and abnormal cellular metabolism significantly contributes to cancer onset and progression. Here, we report that miR-29b negatively regulates AKT2/AKT3 expression, causing HK2/PKM2 downregulation and leading to a decreased Warburg effect and slowed ovarian cancer progression. Compared to normal ovaries, ...
متن کاملmiR-146a Exerts Differential Effects on Melanoma Growth and Metastatization.
UNLABELLED Malignant melanoma is the most aggressive form of skin cancer; therefore, it is crucial to disclose its underlying molecular mechanisms. MicroRNAs (miRNAs) are small endogenous noncoding RNAs able to posttranscriptionally downregulate the expression of direct target genes. Using a melanoma progression model, miR-146a was identified as a key double-acting player in melanoma malignancy...
متن کاملExpression of miR-29b in Malignant Tumors
MicroRNAs (miRNAs) are a class of single-stranded small molecule RNA with about 22 nucleotides in length (Bartel, 2009). These short RNA molecules are able to bind to specifics sites typically present in the three prime untranslated region (3’-UTR) of their target genes and mediate either mRNA decay with perfect base pairing or translational blockade with imperfect base pairing (Pillai et al., ...
متن کاملmiR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2
Glioblastoma multiforme (GBM) is the most common malignant brain tumor and exhibits aggressive and invasive behavior. We previously identified four miRNAs-miR-29b, 494, 193a-3p, and 30e-with enhanced expression in GBM following treatment of ionizing radiation by miRNA microarray analysis. In this study, we found that only miR-29b inhibited tumor cell migration and invasion by reducing MMP-2 act...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2017
ISSN: 1475-2867
DOI: 10.1186/s12935-017-0476-9